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Paul's Nutritional Supplement Regimen Changes - Historical



CHANGES
Here are the reasons for any deletions, additions, and modifications to my nutritional supplement regimen after 03/01/2001.

3/06/01 Found strong evidence today that niacin induces insulin resistance in healthy individuals. Decided to alter regimen by replacing all Hi Niacin LE Mix with Lo Niacin.
4/30/01 Links to Libertarian Solutions deleted until their website contains descriptions. Deleted Only Trace Minerals because of excess manganese, and unnecessary extra zinc. Added chromium and vanadyl sulfate to make up for that removed by above deletion.
Corrected typo on dosage of Super MiraForte. Cell Forte to be taken on empty stomach for probable better absorption. Replaced tyrosine+ and B6 powder with tyrosine and pyridoxamine. Added Chloroplex for copper, carotenoid complex, and chlorophyl.
Split daily cocktail into 2 servings for more even distribution of nutrients.
5/22/01 Added Chloroplex which had been inadvertently left out of 4/30 changes.
5/25/01 Idebenone purchased from Vitamin Research Products; no deep link possible - info available with search.
6/6/01 Note 4) for clarification.
Centrophenoxine, Deprenyl, Pikamilone, Piracetam purchased from Cellcare for significant monetary savings; no direct deep link possible - info available with further link.
Link to Libertarian Solutions re-established; supplement descriptions again available.
6/15/01 Note 2) modified.
Schedule modified to allow sleeping during cooler hours and to evaluate restfulness compared to 28 hour schedule.
Started Pyradoxamine (anti-glycation inhibitor) since other B6 forms (major item tyrosine +) eliminated.
6/22/01 Began taking hydergine for its potential to increase brain blood flow and oxygenation.
7/1/01 Started American Ginseng prior to meals because of evidence that it lowers postprandial glucose peak.
7/17/01 Eliminated links to Cellcare (Centrophenoxine, Deprenyl, Hydergine, Pikamilone, Piracetam) and Libertarian Solutions (Aminoguanidine, KH3, Metformin/Glucophage, Pyritinol) both of which have not completed shipment of 6/4/01 orders, have not responded to e-mail communications, and appear to have fallen prey to local government officials. New sources of these supplements are under investigation.
Split aminoguanidine to half, twice daily since tablet splits easily and less concentration should have less harmful effects.
Doubled pikamilone dose after initial low startup showed no ill effects and split to twice daily.
9/09/01 Separated daily pre-breakfast powders into 2 groups -
1) a meal cocktail which is probably best taken in a distributed fashion to maintain at a constant level, is not harmed by being taken with food and may even be digested better, and may even prevent harmful oxidation and glycation reactions in the food during digestion; and
2) a morning potion which may be best when taken on an empty stomach.
Increased Rhodiola extract to 200 mg daily as planned divided into 3 meal cocktails.
Started Phenacyldimethylthiazolium chloride (ALT-711) to reverse glycation damage ("break" AGEs).
Started Turmeric in meal cocktail and sometimes as spice with food. This was to replace the curcumin capsules which were discontinued because I don't want to take the piperine.
Discontinued Super MiraForte w/Chrysin because of piperine contents.
Changed nighttime Choline Chloride with B5 (no longer available) to Choline Bitartrate and added 250 mg B5 to it.
Included Vanadyl Sulfate; failure to include in error.
9/28/01 Reduced Max EPA to those days when salmon not eaten in main meal.
Changed Ester C to between meals and bedtime to spread more evenly through day with 1000mg in LEF Mix at each meal.
10/7//01 Increased Phenacyldimethylthiazolium chloride (ALT-711) towards goal of 1mg/kg.
Clarified Astaxanthin as 2%.
10/27//01 Added "generic" to (ALT-711) - Phenacyldimethylthiazolium chloride for clarification because, while the substance we are taking appears to be identical chemically to what Alteon has named "ALT-711", it is not made by Alteon. Provided link to LEF Forums thread about this chemical.
Started Brite Eyes to hopefully reduce age-related vision changes and to assist prevention of age-related degenerative eye diseases.
Added acarbose (generic name for Precose in US and Prandase in Canada - a prescription glucosidase inhibitor; obtained from cooperative physician) before each meal to slow carbohydrate digestion and reduce post-prandial glucose/insulin rise.
Deleted aminoguanidine from regimen because its overall value is considered negative now that I am taking both generic ALT-711, and pyridoxamine.
Deleted hydergine, KH3, phenytoin from regimen because of considerations related to difficulty of purchase and lack of evidence of benefit for life extension purposes.
Revised Note 2 back from "summer schedule".
11/5/01 Increased Phenacyldimethylthiazolium chloride (generic ALT-711) to goal of 1mg/kg.
12/4/01 Started N-tert-butyl hydroxylamine (NtBHA) at 15 mg daily towards goal of 1/2 mg/kg daily.
Sports Ginseng supply exhausted; taking American Ginseng for its serum glucose reducing effects since 7/1
12/21/01 Provided links to Research Chemical page of MoreLife for Phenacyldimethylthiazolium chloride (generic ALT-711), N-tert-butyl hydroxylamine (NtBHA), and Pyridoxamine.
Increased NtBHA to 30 mg daily which is our desired dosage goal for now.
Increased generic ALT-711 to 90 mg daily (1.5 mg/kg) which is a 50% increase above our original goal to see if any effects can be detected.
Rearranged timing of American ginseng and glucosol to consolidate pre-meal supplements and promote schedule adherence.
Updated prior changes not already complete.
Increased Brite-Eyes to maximum recommended dose since no changes noted and to utilize more liquid before expiration date. Discarded first bottle after 5 weeks when stinging of eyes occurred with instillation.
12/28/01 Links provided to IAS (International Anti-Aging Systems) new source of Metformin, Lucidril and Piracetam
Deleted Pikamilone; insufficient evidence that cost-benefit ratio for LE is sufficient for the expense and difficulty of purchase.
1/6/02 Added Bacopa and L-Pyroglutamic Acid to meal cocktail. Bacopa has considerable research support of benefit for brain health, and pyroglutamic acid is a "smart drug" with cholinergic function which may have some of the effects of piracetam with which it is chemically similar.
Moved Taurine from pre-breakfast drink to meal cocktail to distribute more evenly through day.
Changed Niacinamide from tablet to powder.
Clarified in Note 4 that no association exists with suppliers nor remuneration received for providing links to source of our supplements.
1/17/02 Increased BHT from 100 mg to 200 mg daily based on recent positive abstracts and its low toxicity.
Corrected BHT volume measurement - typographical error (this had not affected our intake since we always weighed).
Returned to use of CDP Choline which was removed from Cognitex some time ago, after a list of abstracts was posted (LEF Forums link currently unavailable) showing its great value independent of other choline forms.
1/23/02 Added to Note 1 link to powder density data vs. label information.
1/29/02 Created a new Note 3 and feature for most recent changes.
2/6/02 Broke links to BAC. Will seek new source of supplements previously obtained from BAC as supply is exhausted. Although Tom (as Paul Wakfer) has been a customer of BAC for 20 years, the recent response by Erik Cochrane BAC VP (Google post from Kitty Antonik Wakfer 2/4/02) demonstrates a company attitude that we can not support with our business.
2/10/02 Created links to Powder Mixing portion of Supplements in Practice page of website
Corrected 12/4 Change to include deleting of Sports Ginseng at that time.
Deleted NADH; insufficient evidence that cost-benefit ratio for LE is sufficient for the expense. Also taking Niacinamide which is a precursor.
2/18/02 Adjusted Morning Potion table: volumes to reflect measured densities as reported; weights of Rutin, Folic Acid, Hesperidin, Lysine, and Tyrosine brought to even amounts for simplification.
Adjusted Meal Cocktail table: volumes to reflect measured densities as reported; weight of Taurine brought to even amount for simplification.
Note 1 modified to include change in powder volumes.
Note 4 * changed to **.
Removed Pyroglutamic Acid when supply ran out because we had now received more piracetam.
Changed Chloroplex to bid from tid because I eat so many vegetables plus lutein and other mixed carotenoids.
Discontinued CranMax because of eating lots of cranberries and other berries daily.
Removed Ester C from table of meal supplements to reflect 9/28/01 Change.
Changed Grape Seed-Skin Extract to Grape Seed Extract to reflect LEF product change.
Discontinued Indole-3-Carbinol because I eat so many cruciferous vegetables.
Discontinued acarbose because of high price/prescription and taking many other glucose reducing chemicals.
Adjusted all Before Bed powder measurements to reflect measured densities as reported
3/03/02 Changed Age to 64 (Happy Birthday, Tom! **Kitty)
Major formatting changes for improved user intra-site accessibility.
Added Biotin and Creatine to Meal cocktail. Biotin helps with insulin resistance and is inhibited by alpha lipoic acid. Creatine is a direct source of energy for mitochondria, bypassing some of the preparatory steps.
3/08/02 Corrected link to Kyolic Formula 102
Added Vitamin D3; research evidence as anti-carcinogenic, beneficial for calcium metabolism, and not toxic in doses up to 2000 IU daily.
Increased NtBHA to 60mg from 45mg daily in Meal Cocktail.
Added weight apportioned dosage for Morning Potion.
3/18/02 DHEA removed from Regimen listing. New personal stock supply seized by Canada Customs at border as being in violation of Controlled Drugs and Substances Act Schedule IV 23. Anabolic steroids and their derivatives including: (36) Prasterone (3--hydroxyandrost--5--en--17--one) (Schedule I to IV Synonyms). Part 1 Offense and Punishment.(7); penalty of CDN$770 imposed for the return of vehicle from which DHEA was seized.
Acetyl-L-Carnitine removed from Regimen listing. New personal stock of Acetyl-L-Carnitine seized and forced to be "abandoned" as a substance in Part I of Schedule F of the Food and Drug Regulations, which are forbidden to be sold in Canada. Consolidation of the Food and Drugs Act and of the Food and Drug Regulations. No specific text found regarding prohibition against possession of acetyl-l-carnitine; law allows great latitude for creation of new regulations "respecting the importation of foods, drugs, cosmetics and devices in order to ensure compliance with this Act and the regulations;" (Section 30 (1)(d)). "..the Governor in council may make such regulations governing, regulating or prohibiting (a) the importation into Canada of any drug or class of drugs manufactured outside Canada," (Section 30 (2)).
4/15/02 Deleted Only Trace Minerals after deleting supply (being taken only every 3rd day due to excessive Manganese); sufficient amounts of manganese,copper, and boron in LEF Mix and Bone Assure.
Added Optizinc 30mg ad (every other day): provide zinc missing with deletion of Only Trace Minerals.
Deleted Chloroplex; sufficient quantities of vegetables and other vegetable supplements eaten daily.
Moved Cat's Claw extract from Morning Potion to lunch supplements; replacement found in capsule only.
Added Aminoguanidine to Meal Cocktail.
Added R(+) alpha lipoic acid to Meal Cocktail.
Removed Super Alpha Lipoic Acid from each meal and bedtime, and increased Biotin in Meal Cocktail to compensate for loss from capsules.
Clarified that Meal Cocktail powder mix is added to breakfast smoothie just prior to eating.
6/8/02 Corrected stated Folic Acid (10%) measured quantity from 40mg to correspond to actual amount taken since site beginning.
Deleted Udo's Choice as "cost measure"; replaced with Flax seed ground daily. (See Smoothie)
Corrected Magnesium Oxide (60%) quantity from 500mg to actual amount taken since change 02/01
Increased NtBHA from 1 mg/kg) to 1.5 mg/kg
Increased generic ALT-711 from 1.5 mg/kg to 2 mg/kg
Removed Mega Lycopene from list; deleted in March because we already take Super Lycopene which contains other carotenoids in addition to lycopene and we eat plenty of tomato products also.
Increased time before meals for taking American Ginseng based on re-reading the study where it lowered post-prandial glycemia.
Deleted Brite Eyes; found it difficult to remember to take and did not detect any changes after 2 bottles.
Corrected dosage of Cat's Claw to agree with new product; new link provided.
Increased dosage of Metformin to 500 mg twice daily from 250 mg twice daily to reduce fasting glucose, increase insulin sensitivity and decrease between meals gluconeogenesis.
Provided link to new source of 4-Androstenediol.
Modified Note 4 to remove reference to supplier link visible in taskbar; use of Javascript has eliminated this feature.
Changed amount of jointly mixed powders taken to 120% from 110% to be in line with current weight, and realization that amount of nutrients taken should be proportionate to lean body mass, not total mass. It is one of the advantages of powders that they allow finer adjustability.
7/6/02 Bacopa supply exhausted; insufficient evidence that cost-benefit ratio for LE is sufficient to warrant locating new source.
Deleted Chondroitin from regular usage because it may promote insulin resistanceR; It will be used only acutely for joint discomfort.
Added Oil of Oregano; a potent food antioxidantR and antimicrobialR.
Added Nettle Leaf Extract; because of its potent anti-inflammatory effectsR.
Added MGN-3; for anticancer immunotherapeutic benefitsR.
Niacinamide in meal cocktail replaced with capsules obtained in local health food store; name brands depending on price.
Avena Sativa powder within breakfast smoothie replaced with tablets.
9/9/02 Astaxanthin in meal cocktail replaced with capsules R1 R2 R3
Reinstituted Chondroitin twice a day to eliminate periodic aching left thumb and left knee.
Added Calcium Pyruvate to enhance mitochondrial energy output R1 R2 R3
Replaced Chromium tablets with Citrichrome to avoid confiscation by Health Canada
Replaced Cognitex w/ Pregnenolone to w/o version to avoid confiscation by Health Canada; increased dosage to 2 each meal in accord with new version
Added Cordyceps R1 R2
Added Gamma E Tocopherol/Tocotrienols (new studies showing more benefits R
Increased Glucosol to before supper as well as breakfast to aid in lowering blood sugar
Added Inosine to meal cocktail R1 R2
Reduced MGN-3 to 1 capsule before meals after 3 weeks as recommended by mfg
Added L-Pyroglutamic Acid R
Added Chelated Molybdenum Rpp 292-293
Added Zeaxanthin w/ lutein
Eliminated ChronoForte (to eliminate the racemic alpha lipoic acid. All its other ingredients are now taken separately)
Increased Optizinc to every day (to replace that lost from Chronoforte)
Increased Nettle Leaf to before each meal (to replace that lost from Chronoforte)
Increased Acetyl-L-Carnitine to 3x a day (to replace that lost from Chronoforte)
Added Super Carnosine at 2x per day (to replace that lost from Chronoforte)
Created Separate Change Record Page for improved readability
Created print page breaks on Regimen page for separate page printing - select "frames individually"
11/18/02 Added cider vinegar to meal cocktail. Though there is no evidence of benefit, there is also no evidence of harm in moderation and it makes the meal cocktail far more palatable.
Added vegetable juice as option to tomato juice for breakfast potion and meal cocktail. Gives variety of flavor and perhaps additional carotenoids.
Started Brite Eyes II (about 10/10/02). We have also now stopped use of Brite Eyes II (11/16/02). With pretty intensive use, no benefit was found and there is some controversy within the supplement industry, over whether the N-acetyl-L-carnosine is being converted to carnosine in the eye at all. (NALC has no value by itself).
Recorded elimination of Tribulis upon exhaustion of supply approximately beginning of September; not seeking another source
Increased Oil of Oregano to 2 drops. The use of apple cider vinegar allows this amount to still be palatable.
Increased R+ alpha Lipoic Acid from 300mg daily. More and more evidence of special benefit pours in, so we decided that a little more would be better.
Added SE-Methylselenocysteine. A unique and possibly less toxic selenium containing amino acid which is the major selenocompound in selenium enriched plants such as garlic, onions, broccoli florets and sprouts, and wild leeks.
Exhausted Rhodiola powder; replaced with tablets.
Increased Acetyl-L-carnitine to 4 times/day by adding bedtime dose. This increases the dosage to 2 grams daily. There is increasing evidence that the original concern about high moderate amounts being potentially pro-oxidant was incorrect.
Corrected Super Carnosine to twice daily on list per Change 9/9/02.
Deleted Niacinamide supplementation because of growing conflict about potential benefit versus harm. Plan to resume using Hi-Niacin LEF Mix as current Lo-Niacin supply is used up.
Added paragraph to Notes Introduction regarding contents of list as goal vs current usage.
12/01/02 The following changes have been made as a result of analysis of Paul's recent complete set of blood tests. The regimen has not yet been changed because these alterations are only being made for experimental purposes until another set of tests in three months and, thus, they are not the stabilized best estimation of what should be taken at the present time.

For liver and homocysteine: Add LEF's Silymarin in addition to Silibinin. Double dose of B12 and folate. Cease taking aminoguanidine (it binds with B6). Already increased the daily dosage of RLA.
For additional anti-inflammatory effect: Double intake of SuperMax EPA. Add LEF's DHA/GLA as soon as available and delete Mega GLA. Increase daily aspirin dose to 200 mg.
For prostate support and to combat/lower estrogen: Double dosage of Natural Prostate, Avena Sativa Oat Complex, Mega Soy and Natural Sleep (melatonin). Cease taking Pregnenolone, DHEA and Androstenediol.
2/28/04 Changes have not been made as a result of the laboratory testing done in January 2004 because these were incomplete and retesting has been delayed due to LabCorp and LEF paperwork errors. The changes made below are therefore based on previous lab work and partial current lab work.
With respect to the temporary changes noted in the 12/01/02 entry here is the current disposition of those supplements:
Reinstated Pregnenolone and DHEA - decided that it was not the cause of previously high PSA and estradiol or low testosterone.
Eliminated 4-Androstenediol - because it seemed to be producing more estradiol than testosterone for Paul.
Increased Super Max EPA - because decreased number of salmon meals, recommendations of LEF and Twinlab for increased dosage, and increased scientific evidence of benefit for EPA.
Returned Melatonin, B12, folate, taurine, and Mega Soy to prior dosages.
Restarted Aminoguanidine because the best evidence now shows that aminoguanidine inhibits glycation by different mechanisms than other chemicals and is likely quite safe if as least 3 times by weight of B6 is taken with it.
Started LEF's DHA/GLA - for increased anti-inflammatory and neuroprotective effects but only at half recommended dosage because EPA, DHA and GLA are also taken in other supplements.
Continued to take Mega GLA.
The increased daily aspirin dose of 200 mg has become permanent.
Avena Sativa Oat Complex now taken with every meal to help testosterone production.
Natural Prostate was slightly reduced to 3 a day for anti-hormone cancer effects.
Added Silymarin to Silibinin+ - for extra liver protection since it is not totally proven that all the benefits of silymarin are included in silibinin.

The following are additional changes implemented at various times during 2003:
Meal Cocktail powders are no longer mixed with smoothie - to improve taste of smoothie Increased Arginine - produces nitric oxide for vasodilation, promotes wound healing, collagen protection and anti-glycation.
Increased Natural Growth Hormone Releasing - decided that 6 per night was a better dosage for Paul's weight.
Forskolin (additionally w/ each meal) - bedtime pills and powders are often missed and there is evidence that forskolin may be valuable for many health and antiaging axes.
Added ginger to breakfast powders - ginger has been shown to promote insulin sensitivity and lower blood glucose.
Added LEF Mix w/ Niacin - this because of new evidence that niacin is beneficial and better than niacinamide which may even be somewhat harmful.
Added Inositol hexanicotinate - this no-flush niacin form allows an increase of Niacin to a total of over 1 gram daily.
Added Regimint - helps with digestive motility and Kitty was often slightly constipated in spite of lots of fiber.
Added EUK-189 (ramping up slowly to 30 mg daily) - this is a new Super Oxide Dismutase mimetic that we are trying out.
Added Resveratrol - because it is now available and has excellent evidence of benefit.
Reduced generic ALT-711 - latest trials show that a little less may be better.
Reduced Phosphatidylserine - both to reduce cost burden on LEF and because 100 mg is included in Cognitex.
Reduced Low Niacin LEF Mix - because we increased the Mix with niacin.
Eliminated Centrophenoxine (Lucidril) - difficult and expensive to procure and with no recent evidence, value for a very healthy person relative to other chemicals taken is questionable.
Eliminated Idebenone - found studies which indicate it might have a negative effect in mitochondria.
Eliminated Huperzine A - may over-inhibit acetylcholinesterase, might particularly be contraindicated for a person with manic tendencies and no needed by a very mentally health person.
Eliminated Gugulmax - no longer carried by LEF, and not sufficient evidence of value to seek a full price source.
Eliminated extra Niacinamide - per reason given above with respect to adding LE Mix with Niacin.
Eliminated Chelated Molybdenum - because LE Mix already contains it.
Eliminated OptiZinc - merely because we are getting 50+ mg from all other supplements and food sources.
Eliminated Pyritinol - decided that it was not worth the expense and procurement difficulty at this time.
Replaced Oil of Oregano drops with capsules - merely because LEF discontinued the drops.
Replaced L-Lysine, Inosine and Taurine powder with capsules - merely for ease of use, to reduce Kitty's powder mixing burden.
Replaced Cognitex w/Pregnenolone to form w/o
Included skin care products under Topicals for completeness.
PRN Items taken when "under the weather" added for completeness.
Increased Paul's age - Happy Birthday!
3/28/04 Added Policosanol - to maintain low serum low density lipoprotein (LDL) levels and raise high density lipoproteins (HDL).
Amplified Note 2 for 24 hour days and corresponding supplement schedule.
Correction to show Benfotiamine in meal cocktail, started in July 2003 and increased gradually to present dose.
Correction to reason for usage of Regimint - ensure soft regular stool w/o diarrhea.
Revision to reason for ginger usage - Has been shown to lower the average blood glucose level and cause a decrease in serum cholesterol, serum triglyceride and blood pressure in diabetic animal models. Has been shown to significantly reduce platelet aggregation and prevented the decrease of fibrinolytic activity after a fatty meal in human volunteers.
No further changes with the completion of laboratory testing and evaluation of results.
4/30/04 Corrected Pyridoxamine dosage to 300mg daily in Meal Cocktail - increase made Fall 2003 with elimination of other sources.
Corrected Turmeric to 4g daily in Meal Cocktail - increase made Spring of 2003 - based on more evidence of benefit and low rate of absorption.
Corrected Calcium Pyruvate, Chlorophyllin w/zinc capsule dose.
Corrected approximate volume quantities to correspond with actual weights (based on calibrated densities)for Folic Acid, Herbal Mix, Rutin, Biotin, Lutein.
Corrected quantity of GLA/DHA, MGN-3, Vit B1 to what has actually been taken .
Corrected missing Healthprin - has been taken regularly as shown since mid 2003.
Corrected missing Olive Leaf Extract - has been taken regularly as shown for most of period since early 2001.
Corrected missing Inosine capsules - replaced powder per 2/28 Changes.
Corrected missing Natural Prostate - has been taken per 2/28 Changes.
Corrected missing pre-lunch Methylcobalamin - has always been taken.
Clarified L-Pyroglutamic Acid before breakfast and supper.
Changes corrected to note that Silymarin not added to regimen in addition to Silibinin +; dosage of Silibinin + was instead increased from bid to tid in Dec 2002 and remains at that level. 180 mg silymarin contained in 3 capsules of Silibinin + considered sufficient.
Resveratrol once daily changed to with breakfast because of its need to be taken with quercitin for full effectiveness (see MoreLife Yahoo discussion).
All ingredients from Morning Potion moved to Meal Cocktail, except L-arginine and L-tyrosine, thus providing distribution throughout the day and reducing powder mixing task.
Increased Micronized Creatine because of increasing evidence of benefit for the brain.
Added new source for BHT.
Numerous product link updates.
8/8/04 Added Oil of Cilantro - because of its benefits as an antibacterial and heavy metal chelator and its now being available from LEF.
Added Vitamin B-2 capsules - Riboflavin is basic to so many biochemical processed that it was decided to take a little extra from a separate source.
Added Lithium Carbonate - several studies have shown small chronic dosages of lithium protect the brain from various stressors.R
Increased Indole-3-Carbinol and Resveratrol by replacing the plain I3C with Indole-3-Carbinole w/ Resveratrol - I3C was increased because of increasing evidence of prevention of many forms of cancer (particularly sex hormone related cancers) and the fact that 3,3'-diindolymethane (DIM) while being a derivative of I3C, is clearly not the only beneficial such molecule. This new product was used in order to take more resveratrol also in a distribute fashion.
Increased Micronized Creatine - because of increasing evidence of brain benefitR.
Increased generic EUK-189 to target dose.
Increased R-alpha lipoic acid - to the level used in recent positive animal experimentsR1, R2
Increased frequency of Super K - on the basis of increasing evidence for benefit and lack of evidence of harm. Also because the LEF product contains both kinds of K.
Reduced DMAE - we are using this product partly as a replacement for centrophenoxine (of which it is a major part) and reduced the dosage after noticing that DMAE is only about 1/3 the molecular weight of centrophenoxine.
Reduced Super CoQ-10 - a rat study showed extended lifespan with a human equivalent dosage of about 60 mg/day and a previous LEF study had showed no lifespan extension in mice with a higher dosage.
Replaced SuperMax EPA/DHA (liquid) with Mega DHA/EPA (capsules) - taken daily with meals will eliminate occasional forgetting to take liquid on "no fish" days (and the taste of the liquid which Kitty finds unpleasant).
Replaced source of Cat's Claw; no longer available from LEF.
Replaced source of No-flush Niacin; now available from LEF.
Replaced Piracetam tablets with powder as cost saving.
Replaced Super Lycopene with Mega Lycopene - LEF no longer carrying the Super version.
Resumed taking OptiZinc - many animal results suggested that 80-90 mg daily was a beneficial and unharmful dosage.
Corrected listed dosage of Astragalus and Calcium Pyruvate.
10/15/04 Including nutritional seeds on Regimen rather than only in smoothie recipe for consistency with Kitty's page.
Added unhulled hemp seeds - high source of protein and omega-6 fatty acids.R
Increased soy powder in smoothie breakfast powders.
Replaced MGN-3 with AHCC; same amount of mycelia extract in fewer capsules. Change made due to availability from LEF.
Moved Pantothenic Acid (Vit B5) and Choline Bitartrate from bedtime to morning before breakfast because it may have been negatively affecting Kitty's sleep and "energizing" nutrients are needed by Paul in the morning.
Corrected Cinnamon in Breakfast Powders to 1.0 gram; have been taking cinnamon since approximately Feb 2002 with increase from 650 mg to at least 1.0 gram end of last year.
Corrected ginger quantity in Breakfast Powders.
Adjusted L-Arginine volume measurement with new shipment to maintain approximate desired amount by weight.
Modified Note 2) - 24 Hour days.
11/3/04 Corrected quantity of flax, sesame and hemp seeds shown for daily intake within 4 day smoothie mix.
Modified presentation of Meal cocktail to make more clear what is the daily amount of each item taken.
Modified BHT mixture in Meal Cocktail by dissolving it in 20 days total of 375 ml of olive oil and apportioning into juice with powders. This was done because the BHT crystals as mixed with the other powders did not dissolve in the tomato juice/olive oil/ powder mixture, which caused some of it to remain as crystals adhering to the glass after one drank the "cocktail" and thus, not always get ingested.
Modified presentation of Lithium Carbonate to make more clear the daily amount taken.
2/5/05 Note: The vast majority of the changes below resulted from numerous product changes by LEF from which we get most of our supplements free under a long-standing payout agreement (See Note 3).) We have not changed our minds in any major manner concerning the supplement ingredients that we wish to take.

Added R-dihydrolipoic acid capsules; since R-ALA is now available from LEF. We think this unoxidized form will be oxidized during digestion and will give no additional benefit over what we have been taking for years, but it also will not be worse.
Added Curcumin with Bioperine; curcumin is so beneficial that we decided to take the chance on the effect of Bioperine on the P450 enzymes, in order to get more curcumin absorbed.
Added Mitochondrial Energy Optimizer w/ SODzyme; this is a multi-nutrient capsule that replaces all of our carnosine, most of our acetyl-l-carnite and some of our R-ALA and benfotiamine, in addition to supplying other potentially beneficial chemicals.
Added Rosmarinic Acid Extract; in order to get more of the beneficial (antiinflammatory) effects from rosemary than can be obtained from using it as a seasoning.
Deleted Carnosine capsules; equivalent amount contained in new item, Mitochondrial Energy Optimizer.
Deleted Super K capsules; 10 mg daily is contained in LEF Super Booster.
Deleted LEF Mix w/ Niacin; LEF drastically reduced the amount of extra niacin in it and that made the bother of using two different products (with and without niacin) not worthwhile. We increased our No-Flush niacin to make up for the loss.
Deleted Mega Lycopene; It only contains lycopene which we now get in increased dosage from other products.
Increased amount of Folic Acid Powder due to change in mixture by LEF - was 10% pure, now only 0.13% pure - for details see MoreLife Yahoo Post 837.
Increased Chlorophyllin with Zinc to maintain zinc intake with decrease of quantity from change to Bone Restore and decrease of quantity in LEF Mix. The extra chlorophyllin is beneficial also.
Increased amount of L-Lysine taken; resulted from increased per capsule amount by LEF.
Increased amount of low niacin LEF Mix; to replace the deleted LEF Mix w/ Niacin.
Increased amount of No-Flush Niacin; to replace quantity from former and now deleted LEF Mix w/ Niacin.
Increased amount of Melatonin; no longer experiencing next morning drowsiness.
Replaced Tocotrienols with Tocotrienols w/lignans and increased to 2 a day; this is a replacement product by LEF to give better absorption, but we have increased the amount since LEF also removed the tocotrienols from all their other products.
Reduced Vitamin D3 to lunch only; because larger amounts are now contained in other LEF products.
Reduced quantity of RLA powder; with addition of R-dihydrolipoic acid and potassium R-lipate from LEF Mitochondrial Energy Optimizer.
Reduced benfotiamine; because some is contained in LEF Mitochondrial Energy Optimizer.
Reduced Methylcobalamin by eliminating lunch dose; decided there was sufficiently more in other LEF products.
Reduced Acetyl-l-carnitine capsules to night only; the rest is contained in LEF Mitochondrial Energy Optimizer.
Reduced Citrichrome; to compensate for increased chromium in LEF Mix.
Included HCA Citrimax (hydroxycitric acid); to compensate for reduction in amount from reduced Citrichrome Reduced Indole-3-Carbinol w/ Resveratrol from 3x daily to 2x; suggestion that too much might not be beneficial
Replaced Bone Assure with Bone Restore; this new product has more D3, more boron, less manganese, no pyridoxine, more silicon, a little more magnesium and more and a better form of calcium (all of which are good). It also has less zinc, no copper, no TMG and no folate (bad but we have replaced them elsewhere). We expect Bone Assure will soon be discontinued.
Replaced Mega EPA/DHA with Super EPA/DHA w/Lignans; this is a replacement product by LEF to give better absorption.
Replaced Mega GLA with Mega GLA w/Lignans; this is a replacement product by LEF to give better absorption.
Replaced Super Green Tea Extract with Mega Green Tea Extract; this is a replacement product by LEF.
Replaced Mega Soy Extract with Super Absorbable Soy Extract; this is a replacement product by LEF.
Replaced CoQ10 with Super Absorbable CoQ10; this is a replacement product by LEF, but it no longer contains tocotrienols.
Replaced Gamma E tocopherol w/Tocotrienols with Gamma E Tocopherol w/lignans; this is a replacement product by LEF to give better absorption, but does not include tocotrienols.
Replaced LEF Booster with Super Booster; product contains zinc, vitamin K, chlorophyllin, extra ginkgo biloba and sesame lignans, but no tocotrienols and grape seed extract.
Replaced toasted hemp seeds in breakfast powders with first pressing extrusions of unhulled hemp seeds.
Replaced LEF brand Goldenseal with Natures Plus carried by LEF; elimination of own product by LEF.
Replaced Lubriderm with LEF Rejuvenex body lotion; availability only.
Modified location of Ester C; has been taken only at night for past many months since easier to remember.
Modified amount of vinegar in meal cocktail to 20 grams; studies show this amount prevents postprandial glucose rise.
Changed source of American Ginseng and Cat's Claw; NOW brand American Ginseng no longer available at iHerb, previous source for both.
Corrected Resveratrol entry from twice daily to once daily; we had actually already reduced this earlier when we began to take the I3C with resveratrol included.
Corrected Choline Bitartrate and Pantothenic Acid entry; now taken in morning instead of before sleep - see change note 10/15/04
Clarification to amount of B5 (pantothenic acid) taken pre-breakfast; it is 1/2 of a 500 mg capsule.
Updated Note 3).
Increased amount of cocktail powder mixing to 30 day quantity to reduce frequency of mixing chore.
4/8/05 Added Ashwagandha Root Powder to Meal Cocktail - it induces "Neuritic regeneration and synaptic reconstruction" R1, R2; and has numerous other beneficial effects on different axes of the body.
Added note regarding supplement ingredient spreadsheet with link.
Increased amount of L-Arginine from 4.8 gm and added it to meal cocktail, removing it from pre-breakfast potion - we decided that its distributed benefits were more important than the potentially GH boosting benefit of a single dose.
Increased Mega GLA w/ sesame lignans from 1 daily resulting from LEF discontinuing Super GLA/DHA.
Increased Super EPA/DHA w/ sesame lignans from 3 daily resulting from LEF discontinuing Super GLA/DHA.
Changed LEF Super Booster from 1 Lunch to 1 Supper - this was due to changes in the LEF product line with respect to all the E vitamers in an effort to better distribute them and the other sub-parts of the Super Booster.
Changed age - birthday!
Grapeseed Extract product change by LEF now contains Resveratrol.
Deleted Super GLA/DHA because product discontinued by LEF.
Deleted Resveratrol (single item product) since it is now contained in Grapeseed extract as well as Indole-3-Carbinol.
7/4/05 Added Arthromax in January (on table but missing from Change Record) as a replacement for Chrondrox (2 each meal) which was begun in July 2004 temporarily for increasingly aching left thumb. Distribution changed from 1B/2L/1S to current 2B/2S because lunch quantity of pills exceeded bottle size. Plan is to continue till end of 2005 and assess any further need.
Added potassium metabisulfite (obtained from wine making store) to morning meal "cocktail" for supplementary potassium in hopes of alleviating leg cramps during last hours of sleep nightly (because this was the only electrolyte for which we might be deficient. Even the small dosage of ~88 mg of potassium daily appears to have greatly reduced their occurrence.
Increased riboflavin (B2) to 200 mg daily, to see if this helps reduce homocysteine.
Reduced Mega Green Tea from 1 each meal since each capsule is more than twice the strength of the previous version and we drink 2 to 4 large cups of green tea daily (Paul drinks more than Kitty).
Removed Benfotiamine from meal cocktail mix when we ran out of it and decided that the benfotiamine obtained in Mitochondrial Energizer was sufficient and the rest would be obtained from one extra 500 mg B1 cap daily.
Corrected the reported weight of Choline Bitartrate being taken.
Indole-3-carbinol increase in resveratrol content from 7 mg to 20 mg per capsule, without any LEF product number change!
Modification of Note 2 for our return to 24 hour days.
Updated Note 3.
Linked items with ** directly to Note 4 for better identification.
9/14/05 Added Echinacea as once daily to bolster immune systemR1, R2 as measure to possibly reduce incidence of recurring mysterious ailment. (Last described in part in portion of Kitty Reflects entry in January 2005. Occurrences 4 times since early June.) Added L-Theanine to before sleep to promote restfulness.
Replaced potassium bisulfate powder with potassium chloride purchased as water softening agent. Even large pieces dissolve easily in water when heated and stirred; added to meal cocktail separately for each meal. Amount taken also increased to original desired amount - 1 gram daily - now that source is plentiful. (No occurences of leg cramps since supplementation started).
Increased Thiamine (B1) from 500 mg twice daily to three times daily.
Moved 500 mg Acetyl-l-Carnitine from before sleep to supper meal to reduce possible neuro exciting/sleep reducing effect.
Changed Indole 3 Carbinol to version with broccoli concentrate rather than resveratrol because LEF added resveratrol to Grapeseed extract.
Temporary hold on generic ALT-711 started with cocktail mix at beginning of August; will continue until full blood work planned for end of October with comparison to "baseline" done on 7/15/05. See discussion.
10/24/05 thru 1/10/06 Added ArthroPro - decided that a combination of ArthroPro and AthroMax might be better than all of only one.
Added Astaxanthin - this carotenoid from sea plant sources may have benefits for humans.
Added Boswella - for its antiinflammatory, antiarthritic benefits.
Added DHEA Complete as replacement for DHEA - decided to try keto-DHEA in addition to regular DHEA for its potential benefits.
Added DNA Protection Formula - for its beneficial amounts of curcumin, chlorophyllin, wasabi and broccoli extract.
Added Iron Protein Plus - only every other day, hemoglobin and iron levels indicated there might be a little deficiency.
Added Maitake SX-fraction - potential anticancer, hypoglycemic, hypotensive and immune boosting effects.
Added Natural Relief COX-2 Inhibitor w/ Nexrutine - antiinflammatory and antiarthritic.
Added PEAK ATP w/ GlycoCarn; constituent propionyl-l-carnitine in addition to acetyl-l-carnitine.
Added Primal Defense (probiotics).
Added Silymarin w/ Isosilybin-B - to have more complete silymarin from two sources.
Added SODZyme + GliSODin - to hopefully increase SOD in the body.
Added Only Trace Minerals taken only once every two days - to increase manganese a little.
Changed Echinacea from only as needed for when feeling "unwell" to twice daily. Mouse studies show prophylactic use is beneficial for life extension.R1 R2
Increased Aminoguinidine from 120mg to 240mg as of December's "meal cocktail"
Increased Branched Chain Amino Acids from 1 to 2 each meal - recently studies show benefit from more dietary Leucine.
Increased Calcium Pyruvate from twice to 3x daily - pyruvate can be the source of energy for the brain.
Increased Herbal Cardiovascular Formula from twice to 3x daily - to get more curcumin and gugulipid.
Increased Lactoferrin from once to twice daily - for its immune system benefits.
Increased Olive Leaf Extract from once to twice daily - because of its benefits.
Increased OptiZinc from once every 3 days to once daily - because zinc was reduced by some other product changes.
Increased Phenacyldimethylthiazolium chloride (generic ALT-711) from 108 mg to 216 mg daily - after found that it had not raised liver enzymes and to see if it would have added benefits.
Increased Phosphatidylserine (PS Caps) from once to twice daily - beneficial for the brain.
Increased Pyridoxamine from 360 to 480 mg daily - for antiglycation benefit and no sign of neurotoxicity from too much B6.
Increased elemental Potassium to ~2.0 grams daily - blood tests and the occasional cramp suggest it was still not enough.
Increased Cinnamon and ginger in breakfast powders - more studies show benefits from both.
Increased amount of olive oil used to dissolve BHT from 525 to 900 ml per 30 days - for benefit of more oil daily and have a graduated bottle that size.
Reduced ArthroMax from 2 to 1 twice daily - because ArthroPro was added.
Reduced Vitamin B1 from 3 times to twice daily.
Reduced Chlorphyllin w/ Zinc from every meal to once daily - because both were in other products now.
Adjusted night powders for Kitty/Paul weight ratio and correct volumes for desired weight.
Deleted Ashwagandha root powder from Meal cocktail - sufficient amounts now present in LEF products.
Deleted Carotenoid Complex - contains too much beta carotene and I now get astaxanthin separately.
Deleted Cordyceps - no longer available thru LEF - replaced with maitake SX-fraction product.
Deleted Glycine - found out it was a major source of methylglyoxal which causes protein glycation.R (Not using up reserve quantity.)
Deleted Mega Green Tea - am already taking enough in other supplements and by drinking, too much extract is not beneficial and may increase homocysteine. (PMIDs 16037419, 16330015) (Not using up reserve quantity.)
Cognitex w/o Pregnenolone product number change by LEF to include new neuroprotective items.
CoQ10 product number change by LEF to include d-Limomene.
Super Zeaxanthin w/ Lutein number change by LEF.
Updated link for Metformin. Removed buckwheat from smoothie ingredients (list of) because it contains trypsin inhibitors that can cause poor digestion if not sufficiently cookedR; eat it only within Kitty's hot cereal or super nutritious pancakes
Increased Pregnenolone from 1 to 2 50 mag capsules daily
2/5/06 Considerable change in amounts of various supplements resulting from the decision to go to two meals per day - see Note 2. Items still taken in same amount daily but only moved to a different meal are not noted in Changes.
Decreased American Ginseng to twice daily - before each meal.
Decreased Glucotrim to twice daily - before each meal.
Decreased Nettle Leaf extract to twice daily - before each meal.
Changed SODZyme + GliSODin to before breakfast per mfgr's suggestion.
Change of Astaxanthin from 1 mg to 2 mg caps - 1 mg being discontinued by LEF and decided more was better.
Change of Healthprin name to Low Dose Aspirin by LEF.
Change to Natural Prostate product by LEF.
Changed link for Deprenyl.
Added Dual Action Cruciferous Vegetable Extract w/ Resveratrol as a replacement for Indole-3-Carbinole w/ Broccoli being discontinued by LEF.
Increased Co-Q10.
Increased CranMax.
Increased TMG to 6 tabs daily (taking 2 at bedtime) for elevated homocysteine.
Increased Methylcobalamin to 5 mg once daily from 1 mg twice daily also for elevated homocysteine.
3/06 thru 10/06 Added Ashwaghanda Extract in July 2006.
Added Natural BP Management in July 2006.
Added DHEA 25 mg product in addition to 50 mg and DHEA Complete for flexibility of dosage.
Added Fibrinogen Resist in October 2006 to get the nattokinase.
Added Immune Protect w/ Paractin in October 2006.
Added Resveratrol via LEF product in July 2006 Deleted Quercetin, Hesperidin, Rutin and Citrus-Bioflavanoid in March 2006 due to possible contribution to elevated homocysteine (reevaluate usage).
Increased generic EUK-189 from 36 to 60 in July 2006 Increased Aminoguinidine from 240mg in July 2006.
Increased Creatine from 6 grams daily in July 2006.
Increased DMAE from 648 mg daily in July 2006.
Increased Natural Relief COX-2 Inhibitor Nexrutine from 1 daily in Spring 2006.
Reduced Alagebrium Chloride (generic ALT-711) from 216 mg daily in October 2006.
Reduced Magnesium Oxide from 1344 mg daily to 600 mg in April 2006 and then to 300 mg in October 2006; held entirely starting November 2006 as attempted measures in response to diarrhea.
Reduced Pyridoxamine from 480mg to 360 mg in June 2006 due to numbness in one finger (possible neuropathy?). Resumed 480 mg in October 2006; no return of numbness.
Replaced Metformin 850mg tabs (1.5 daily) in Spring 2006 due to unavailability with prior source and amount.
Bone Restore product number changed by LEF early 2006; no listed constituent changes.
1/07 thru 4/30/07 Note that some changes were made in order to reduce the volume of pills taken, after the decision to go to one meal daily was taken in January 2007. Deletions made for that purpose only are indicated by the phrase "(volume reduction)". The addition of the phrase "reevaluate usage" means that this deletion or reduction will be subject to later reevaluation.
Added Acipimox early am and HS to increase protein recycling, including those that are dysfunctional. (See separate page.)
Added 4-Androstenediol following lab results of early April 2007.
Added Arthromax and ArthroPro; occasional mild discomfort in certain joints.
Added Benfotiamine with thiamine.
Added Biosil for bone health.
Added D-Ribose to facilitate production of ATP and possibly have glucose lowering effect.
Added Kremezin to meal cocktail; possible inhibition of absorption of ingested AGEs.
Added magnesium citrate to make up for reduced magnesium oxide.
Added Pomegranate Extract.
Added Red Yeast Extended Release to moderate small rise in cholesterol; an herbal statin.R
Added Resveratrol as synthetic powder in meal cocktail in January 2007 as an added source for its multiple benefits.R1, R2, R3
Restarted Quercetin and Rutin; elimination did not effect level of homocysteine and value of their bioflavonoid is high.
Restarted Only Trace Minerals after deletion of Citrichrome.
Increased Cilantro Herbal extract from 20 drops in each meal cocktail to partially compensate for taking only once daily.
Increased Vit-D3 from 1 capsule 1000 IU daily.
Increased Alagebrium Chloride (generic ALT-711) from 108 mg daily February 2007.
Increased generic EUK-189 to present level in February 2007.
Increased GlucoTrim from 2 daily due to larger amount eaten at one time. Increased HCA to gain back that part of the reduced Citrichrome.
Increased R-Dihydro Lipoic Acid from 1 daily.
Increased Resveratrol extract by changing to 100 mg capsules.
Increased Rosmarinic Acid Extract because it is highly antiglycative - http://PMID.us/17385882.
Included L-Arginine in night potion to replace elimination of Natural Growth Hormone Releasing.
Included L-Ornithine in night potion to replace elimination of Natural Growth Hormone Releasing.
Reduced Artichoke Leaf extract from 2 daily (volume reduction); product number change by LEF
Reduced B-1 (Thiamine) from 2 daily due to addition of Benfotiamine.
Reduced DHEA Complete (DHEA/7-Keto DHEA).
Reduced DHEA from 50 mg following lab results of early April 2007.
Reduced Echinacea from twice daily (BID) to as needed only (prn) (volume reduction).
Reduced Herbal Mix from 10.8 grams daily and Lutein Plus from 12 grams daily in January 2007 (volume reduction).
Reduced Natural Prostate from 3 daily.
Reduced Pantothenic acid (Vit B5) from 3.5 caps daily; amount sufficient.
Reduced Potassium from 1.92 grams daily in January 2007.
Holding on Magnesium Oxide still until February 2007 as continued attempted measures in response to diarrhea.
Deleted Boswella; get active ingredient, 5 loxin, elsewhere (volume reduction).
Deleted CDP-Choline (volume reduction - reevaluate usage).
Deleted Citrichrome since other products had increased their Chromium content.
Deleted Citrus Bioflavanoids finally in March 2007 sufficient in smoothie citrus peels (volume reduction).
Deleted Forskolin (volume reduction).
Deleted L-Glutamine as potentially promoting insulin resistance (reevaluate usage)
Deleted HepataPro (volume reduction - reevaluate usage).
Deleted Herbal Cardiovascular Formula (volume reduction).
Deleted Hesperidin finally in March 2007 because sufficient now in LE Mix.
Deleted Inosine (volume reduction - reevaluate usage).
Deleted Ipriflavone; continues to be listed as "out of stock" at LEF.
Deleted Iron Protein Plus; serum iron sufficient level.
Deleted Lactoferrin (volume reduction - reevaluate usage).
Deleted L-Lysine due to its tendency to promote glycation problems.
Deleted Mega GLA (volume reduction).
Deleted Natural Growth Hormone Releasing to eliminate more pyridoxine so it could be replaced by pyridoxamine.
Deleted Olive Leaf Extract (volume reduction - reevaluate usage).
Deleted Tribulus (volume reduction - reevaluate usage).
Deleted Turmeric from meal cocktail; sufficient amount of active ingredient curcumin from other sources.
Changed to Kyolic Reserve to get more aged garlic extract because of anti-AGE evidence http://pmid.us/17321518
Changed to LEF Acetyl-l-carnitine product (optimized w/ Glycocarn) which includes additional forms of l-carnitine.
Low Dose Aspirin product number changed by LEF.
Blueberry product number changed by LEF when Pomegranate extract added.
Super Booster product number changed by LEF; no longer includes zeaxanthin.
Super Absorbable CoQ10 w/ D'Limomene product number changed by LEF; no listed constituent changes.
Curcumin w/ Bioperine product number changed by LEF; content of curcumin decreased from 900mg.
Dual Action Cruciferous product number changed by LEF; addition of Cat's Claw.
Super EPA/DHA product number changed by LEF and name modified; additional olive oil.
Natural Estrogen product number changed by LEF; new formulation.
GlucoFit name change from GlucoTrim by LEF.
Life Extension Mix product number changed by LEF; new formulation.
Silibinin+ product number change by LEF; no change of constituents listed.
SODZyme + GliSODin product number change by LEF; addition of wolfberry.
Zeaxanthin w/ Lutein product number change by LEF; addition of meso-zeaxanthin.
Correction of link for DNA Protection Formula.
Including Ascorbate C powder which has been taken in amount of Paul's smoothie, increased in January 2007 to 40 of total daily amount made.
Modified Notes 2) and 5).
Increased Paul's age - current for birth 2/26/1938.
5/1 thru 6/30/07 Added 5-Loxin - to replace reduction in Nexrutine and to reduce left thumb second joint discomfort.
Restarted Acarbose Spring 2006 (had taken in 2001 & 2002) with periodic temporary stops due to bouts of diarrhea and flatus, both now under control past several weeks.
Add Astragalus Root alcohol-free containing 1mg astragalosides per serving; possible prevention of telomere shortening in addition to many benefits of the herb.
Added (-)-BPAP - for serotonin & dopamine increase.
Added Jarro-Dophilus as an additional probiotics source to reduce diarrhea (after investigation determined to be a result of bowel irritation from taking so many supplements).
Added Panax Ginseng to replace American Ginseng because available from LEF and it should be effectively the same.
Increased Astaxanthin from 2 daily - unique carotenoid with many positive benefits.
Restarted Hesperidin Complex, Olive leaft extract, Mega Green Tea extract & Citrus Bioflavonoid - homocysteine greatly reduced, likely from reduction in methionine intake due to major reduction in meat intake.
Restarted Forskolin - may result in increased SAMe.R
Restarted Lactoferrin - need for total qty reduction reduced.
Replaced potassium chloride with potassium citrate - maintain same potassium supplementation while obtaining the benefits of the citrate moiety among them prevention of uric acid renal calculi (kidney stone) prevention.
Hold on all DHEA except DHEA Complete following May bloodwork results.
Reduced Pregnenolone from 2 daily.
Reduced Ashwaghanda from 3 daily - reduction in total pill quantity, also obtained within Cognitex.
Reduced Chondroitin from 3 daily - reduction in total pill quantity.
Reduced DNA Protection from twice daily - reduction in total pill quantity.
Reduced Ginko Biloba from twice daily - reduction in total pill quantity; sufficient qty from other sources.
Reduced Super Omega 3 - EPA/DHA from 5 daily - reduction in total pill quantity.
Reduced LEF Mix from 8 daily - reduction in total pill quantity.
Reduced MSM from 3 daily - reduction in total pill quantity.
Reduced Rosmarinic Acid from 3 daily - reduction in total pill quantity.
Reduced TMG from 8 daily - reduction in total pill quantity and greatly improved homocysteine level after reduction of meat intake.
Deleted Bone Restore - sufficient quantities of ingredients taken in other items.
Change note that Astragalus extract increase from 1 daily occurred in 1/07 thru 5/1/07 timeframe as for Kitty.
Modification of Natural Relief COX-w Inhibitor Nexrutine to non-food timing in conjunction with mfg recommendation.
Modification of Breakfast Course Powders for current practice.
7/20 thru 9/7/07 Added Endothelial Defense as replacement for Pomegranate Extract and some of SOD-Zyme.
Added Pantothene Coenzyme B5 Precursor. (See sci.life-extension thread http://tinyurl.com/2yk64d)
Increased Astaxanthin from 2 daily; additional benefits.
Replaced Dual Action Cruciferous Veg Extract w/ Resveratrol to w/ Resveratrol & Cat's Claw; replaces separate Cat's Claw.
Correction to show 5-Loxin noted in 5/1 thru 6/30/07 Change Notice.
Correction to show Astragalus Root alcohol-free noted in 5/1 thru 6/30/07 Change Notice.
Correction to show Avena Sativa; has been taken since 2004 but reduced with change to 2 meals daily in 2006 (probably copied over in prior updating).
Correction of Meal Cocktail ingredients by including N-acetyl-L-carnosine (NALC); had been added to regimen in April 2006 at 60 mg daily (50 mg nominal).
Corrected -BPAP to show as taken NF.
Correction to show Ester C being taken regularly, since January 2007 with change to 1 meal daily.
Correction to show Super Carnosine being taken at night.
Correction to show CarnoSoothe, added in February 2007 to obtain zinc carnosine, a time-delayed carnosine.
Correction to show Chlorophyllin w/ Zinc as 2 daily; since change to 2 meals daily in early 2006.
Correction to Forskolin to properly reflect how taken daily, NF and before sleep.
Correction of Inositol volume measurement to reflect weight usage.
Correction to show reduction of MSM noted in June 2007.
Correction to Natural Sleep (melatonin) to reflect dosage that has been taken since 2/2005; apparent transcription error.
Correction to Nexrutine to reflect reduction noted 5/1-6/30/07 and also 2nd dose actually taken at sleep.
Correction to Pregnenolone to reflect dosage taken since May 2007.
Correction to show restart of Super MiraForte; in October 2006.
"Before Bed" replaced with "Before Sleep" for accuracy.
Notation for Change Record on addition of Natural Estrogen - beneficial effects of all ingredients for men as well as women. (see MoreLife Yahoo post #1589 http://health.groups.yahoo.com/group/morelife/message/1589 for discussion.)
Removal of "**" from synthetic trans-resveratrol in meal cocktail; information available only during time of group purchase.
9/23 thru 10/6/07 Increased TMG (betaine) from 2 daily to upregulate Protein-L-isoaspartyl methyltransferase (PIMT) that plays a crucial role in the repair of damaged proteins.R
Increased N-acetyl-L-carnosine from 240 mg daily after review of additional papers (especially PMID 16621390) regarding the potential of carnosine as a powerful glycation inhibitor both extra and intra-cellularly and confidence that NALC is an effective time release form of carnosine that will enable it to get into cells (as it does with respect to eye lens cells in ocular therapeutic applications).R
Added to legend for explanation of items taken multiple times during the day to eliminate confusion by readers.
Corrected product link for l-tyrosine.
10/20 thru 11/25/07 Added Rhubarb root powder to meal cocktail after maximum tolerable level was determined; an abortive attempt made June 2006 at larger quantity - relatively high emodium content aggravated tendency to irritable bowel symptoms, now resolved.R
Changed to using black sesame seeds instead of white - while they are a little more costly, they likely have more nutritive value, but unfortunately there is no published comparison of the two.R
Added Metabolic Modulator (beta glucan oat and barley sprout blend) to lower post-prandial glucose/insulin levelsR1, R2 and promote digestive/colonic health.R
Added SAMe (S-Adenosyl-Methionine) - now that homocysteine is lower and we are less concerned about the fact that all SAMe will be converted to homocysteine, this may increase beneficial SAMe beyond what can be gained by recycling homocysteine or production from methionine (which has also been reduced in our diet).
Deleted folic acid from meal cocktail - because homocysteine is now reduced, there is a sufficient amount from other sources and some studies have shown and expressed concern about megadose amounts. R1, R2, R3, R4
Replaced Curcumin with bioperine with Super Bio-Curcumin - because it is more bioavailable.
Replaced l-Theanine with Natural Stress Relief; includes lemon balm and twice l-theanine amount.
Restarted Regimint; improve intestinal motility now that irritable bowel symptoms have resolved. Restarted rhodiola since irritable bowel symptoms under control and herb has multiple benefits.R (See interesting Science News article.)
Returned Forskolin dosage from 3 to 4 daily now that bowel irritation resolved.
Corrected Resveratrol quantity for NF.
Corrected to remove Bone Restore as noted in Changes 5/1 thru 6/30/07.
Updated Notes 2 and 5.
Added page section for PRN (as needed) item(s) for occasional short-term joint or muscle discomfort - Fast-Acting Joint Formula.
Modified entry for 4-Androstenediol to show no longer available from original source.
12/20 thru 2/26/08 Added Super Polyphenol Extracts w/ Cocoa Gold to have added cocoa polyphenols from another source beyond that included in diet from cocoa powder and dark chocolate plus another source of other polyphenols.
Added Optimized Resveratrol 250 mg as replacement for 100mg x 2NF dosage; 1 less item to swallow.
Added Venotone - to minimize tendency toward varicosities in left lower leg.
Increased LEF's R-Dihyro lipoic acid - bulk supply RLA now exhausted in meal cocktail powder and do not plan to procure more, since we think the LEF product is sufficient.
Increased Hesperidin Complex in Meal Cocktail from 720 mg to compensate for large decrease in LEF Mix.
Replaced Natural Sleep containing melatonin with plain melatonin; eliminates additional source of inositol and 10 mg capsule replaces 2 5 mg capsules.
Replaced NOW brand Cat's Claw self-purchased with LEF product, now available, for reason of no cost arrangement w/ LEF.
Changed Green Tea extract from taking with meal (F) to premeal. R
Deleted Inositol powder; too much inositol may be inhibiting autophagy and opposing lithium. R1, R2
Restarted Gotu-Kola; good for cognitive function and mood disorder. R
Restarted Tribulus; may help raise effective testosterone R and has Antibacterial and antifungal activities R
Updated Blueberry extract link for new formulation by LEF.
Updated Endothelial Defense link for new formulation by LEF.
Update LEF Mix link for new formulation by LEF.
Update of Natural Prostate for new formulation by LEF.
Update of Ubiquinol (CoQ10) link for new formulation by LEF. Correction also to note that Ubiquinol was started November 2006 but was not included previously in Change Notices.
Update of Meal Cocktail note to include Rhubarb root powder now added separately.
Corrected Pre-Sleep Items to include TMG, taken as shown since 9/07 change notice.
Update for Paul's birthday - Happy 70th!
3/13/08 thru 4/11/08 Added Bromelain for anti-inflammatory benefits.15841258 R
Added Standardized Lignan Extract as my only source of Norway Spruce extract; anti-oxidant, free-radical scavanger. R
Added Super Critical Omega 7 (from sea buckthorn) - for its anticarcinogenic properties as well as overall nutritive value. R1, R2
Added tryptophan as regular pre-sleep item chiefly because our dietary intake of this essential amino acid is low.
Added Yohimbe-Plus - claimed for increased stamina, vigor and libido; experimented 3 months at 1 daily & will retain at that level mainly for its worthwhile constituents (stamina, vigor and libido all acceptable).
Increased d-Ribose from 3 grams daily - recommended level for healthy adults for restoration of normal ATP levels in "worked-out" muslces; faster recovery and greater endurance. R
Increased Vitamin D from 2 daily and added larger dose at beginning of mystery leg syndrome episodes - vitamin D up-regulates for cathelicidin, a naturally occurring broad-spectrum antibiotic. R
Increased Dilauryl Thiodipropionate and Thiodipropionic Acid from 60 mg daily each because of removal from LEF Mix formulation.
Increased Optizinc from 1 every 3 days.
Increased Pregnenolone from 1 daily - cholesterol levels low and even with supplementation, serum pregnenolone levels only moderate.
Restarted Echinacea regularly from PRN only - additional study showed ablity to raise erythropoietin (EPO), interleukin 3 (IL-3). R
Increased Lithium from 150 mg every 3 days - evidence of CNS protection. R1, R2
Deleted Metafolin (methlyfolate) - supply exhausted and neither LEF nor any other supplier carrying it (Merck/Eprova AG has withdrawn its production of methylfolate in place of prescription-only mega-dose product).
Decreased SE-Methly-selenocysteine from 1 daily - total selenium intake higher than desired.
Link change for Cran-Max - product number change by LEF; no stated constituent change.
Noting for Change Record that Optizinc was decreased from one daily to one every 3 days in April 2007 when Carnosoothe was added.
4/30/08 thru 6/30/08 Added Astaxanthin 4mg from NOW to replace 2mg from Source Natural - fewer quantity for same total.
Added Citrulline Malate - more effective to raise plasma arginine levels and arginine/ADMA (asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase - and therefore harmful) ratio than supplemental arginine - PMID: 17662090
Correspondingly decreased l-arginine from 7.2 g.
Added Whole Grape w/resveratrol, replacing grapeseed extract w/ resveratrol - to get more whole grape benefit.
Added Super R-Lipoic Acid to replace R-dihydro Lipoic Acid that had been increased after depletion of bulk powder - fewer capules.
Increased Melatonin over several weeks from 10 mg at night to total intake of 40 mg daily spread over the day - following results of studies including recent study and correspondence with author reported at sci.life-extension.
Increased amount from 350 mg daily and modified Resveratrol times from wide distribution without food to all at my single meal - resveratrol may require fat to be well digested PMID: 18486604 and discussion at sci.life-extension newsgroup.
Deleted Quercetin capsules - study result suggests toxic effects on neurons; this elimination reduced total querectin intake to half.
Replaced Metformin 500 mg with Extended Release formulation obtained by prescription and spread 3 doses further apart- no longer readily available from former source, Masters Marketing.
Corrected to show addition of Acai Fruit for usage when in Ontario since frozen pulp not available for smoothie making.
Corrected Alagebrium Chloride to show 144mg actually taken since April 2007.
Noted for Change record that Acarbose was increased from 130 mg immediately pre-meal in late 2007.
Noted for Change record that acipimox was increased from approximate total 220 mg in late 2007.
Noted for Change Record that -BPAP increased from 60 mcg daily to target dose in late Summer 2007.
7/21/08 thru 9/5/08 Added tryptophan (Tryptopure) as regular pre-sleep item chiefly because our dietary intake of this essential amino acid is low.
Increased Hydroxycitric Acid from 3 daily in an attempt to reduce blood glucose level.
Increased Metabolic Modulator from 1 scoop in each smoothie serving which is larger with current eating on only 2 days out of 3.
Replaced Deprenyl tablets with transdermal cream for its transmission to the brain before potentially negative processing by the liver.
Replaced synthetic trans-resveratrol (after exhaustion of supply) used in meal cocktail with increased amount of LEF's resveratrol products containing trans-resveratrol.
Corrected Whole Grape Extract to reflect how actually taken.
Added notation for BPAP drops for completeness.
Moved listing of Metformin Extended Release from meal-related supplements to "Prescription Medications" subsection of page.
Notation for ongoing practice of separate addition of generic Kremezin to Meal Cocktail to avoid settling out in less dense powder mixture.
Added a Definitions section to the Notes for improved clarity.
Modified Note 1 for current practice; refrigeration of Meal Cocktail powder ceased when R-alpha lipoic acid powder no longer a constituent.
Extended Note 2 to reflect change from 1 meal daily to 1 meal on 2 days out of 3.
Change of notations for various items from regarding to "day" to "meal" reflecting current practice.
10/10/08 thru 2/27/09 Added Advanced Lipid Control - new LEF product with unique ingredients beneficial for lipid health, that we did not previously take. See LEF product description for details.
Added Bacopa Extract - new LEF product with unique brain beneficial ingredient, that we did not previously take. See LEF product description for details.
Added Berry Complete - new LEF product with full spectrum berry extracts, some of which we did not previously take. Almost impossible to get too many berries. See LEF product description for details.
Added Bone Strength Formula with KoAct - new LEF product with unique ingredients beneficial for bone health, that we did not previously take. See LEF product description for details.
Added EDTA - because the EDTA was removed from LEF's Pure-Gar and this EDTA-only product has more EDTA so it provides more free heavy metal chelation ability.
Added Fernblock - new LEF product with unique ingredients beneficial for skin health (apart from anti UV radiation benefits), that we did not previously take. See LEF product description for details.
Added Florastor - an intestinal bacteria not contained in other products being used. See LEF product description for details.
Added L-Carnitine - Used to think this form of carnitine was unnecessary when others were being taken but now think it may be beneficial in addition to other forms.
Added Hoodia Gordonii - to decrease or eliminate tendency to mental fatigue on evening of fast. See LEF product description for details.
Added Integra-Lean Irvingia - to increase insulin sensitivity and decrease conversion of glucose to fat, amylase inhibition. See LEF product description for details.
Added Super K w/ Advanced K2 Complex - because of significant decrease of K1 in LEF Booster.
Added Korean Angelica - inhibitor of NF-kappa B activation; an anti-iflammatant. See LEF product description for details.
Added Mega Lycopene - particularly beneficial carotenoid, and prostate disease preventer.
Added Nattokinase - new LEF product to keep blood vessels clear and blood clot-free, that we did not previously take. See LEF product description for details.
Added ProGreens - Best LEF product that we could find to replace discontinued LE Herbal Mix. See LEF product description for details.
Added Propolis Extract - new LEF product to augment immune protection and for other benefits, that we did not previously take. See http://pmid.us/19021816
Added Pumpkin Seed Extract w/soy isoflavone - new LEF product to support urinary tract health, that we did not previously take. See LEF product description for details.
Added Pycnogenol - new LEF product. Well-researched proanthocyanidin that may some benefits beyond other forms, that we did not previously take. See LEF product description and PubMed for details.
Added Vascular Protect - new LEF product to promote heart and vascular health, that we did not previously take. See LEF product description for details.
Restarted Folic Acid powder, LEF 0.13% pure; next meal cocktail powder mix include 100% pure for total 3mg nominal - after previously cutting back, decided that we should increase a little.
Increased Acipimox from .20 mg on meal days + .25 HS - to increase autophagy while fasting.
Increased ArthroPro and ArthroMax from 1F - increased evidence of benefit of glucosamine even without specific joint/ligament disorders, and no ongoing evidence of any pro insulin resistance effect.
Increased micronized creatine to original nominal dosage of 7500mg daily by adding a dose on fasting day - to reduce tendency to mental fatigue late on fasting day.
Increased GlucoFit from 3 to 2 X 2 - to have glucose management for each half of extended single meal on 2 eating days out of 3.
Increased N-acetyl-cysteine - more benefits of this appear on PubMed all the time, particularly lately for brain health.
Increased Pure Gar capsules from 1 daily - More garlic is better both unaged (this kind) and aged (from Kyolic).
Increased Super Ubiquinol CoQ10 from 1 daily - Increasing research showing more benefits.
Decreased Vanadyl Sulfate from 6 daily - It was not benefiting blood glucose level and was concerned about toxicity of vanadium.
Decreased number of items taken Non-Food by moving Cellforte with IP6/Inositol, Natural Relief COX-2 Inhib Nexrutine, PS Caps and Nettle Leaf to HS.
Deleted B1 (thiamine) as separate item and increased benfotiamine from twice daily - There is still plenty of thiamine in other supplements (particularly LE Mix) and benfotiamine has more evidence of benefit all the time.
Deleted -BPAP - Did not sense any benefit, there has been very little recent research (none on humans) and it is costly.
Deleted Policosinol - Less and less evidence of any real benefit in addition to all other things taken.
Deleted SE-Methylselenocysteine - sufficient selenium from other sources including food.
Replaced ArthroPro with ArthroMax - discontinuation by LEF with a new formulation of latter.
Replaced Astaxanthin separately with new formulation Super Zeaxanthin containing astaxanthin.
Replaced LEF's Optimized Cat's Claw w/ Source Naturals brand of bark- LEF discontinued own product.
Replaced Cinulinin with Cinsulin and modified usage - product change by LEF and to provide glucose management for each half of extended single meal on 2 eating days out of 3.
Replaced Metabolic Modulator with Cocoa Gold w/ Beta Glucan - LEF eliminated the former.
Changed CranMax from NF - decrease qty taken.
Corrected Super Ubiquinol CoQ10 to show correct dosage of product.
Corrected Bromelain listing to show usage at HS.
Corrected Echinacea to show usage that has been taking place since Change Notice of 3/13/08 thru 4/11/08.
Corrected Gotu-Kola to show actual usage.
Corrected link for Regimint - thanks to notification of error by Dave Brett.
Corrected Resveratrol 250 mg for more complete product name and correction of 100 mg shown at NF.
Updated links for numerous items that have been changed by LEF. [Booster, lutein plus, ubiquinol, Blueberry, Whole Grape Extract, Mitochondrial Energizer, PureGar (EDTA removed), Super Zeaxanthin, Super MiraForte]
Modified wording for title of main supplement table to clarify when taken in relationship to each meal.
Changed Paul's age - Happy Birthday #71 (2/26/1938)
4/09 thru 11/09 Added Agave Digestive-Immune Support (included in Meal Cocktail) - contains inulins (indigestible fructose polymers), FOS (fructooligosaccharides) and PHGG (partially hydrolyzed guar gum) all for digestive health support - PMID 17711612
Added Arthro-Immune Joint Support - increases amt of Paractin intake & more biocurcumin.
Added B12 Eligen - improved GI tract absorption
Added Black Currant juice extract for inclusion in smoothie & added to hot cereal - contains unique eye protectors delphinidin-3-rutinoside and cyanidin-3-rutinoside - PMID 11134978.
Added Digestive Enzymes, at beginning of both halves of meal - better distribution.
Added Mangosteen 100, juice for inclusion in smoothie - supports healthy immune and inflammatory processes - PMID 18725264, PMID 19172667.
Added l-methylfolate (again available from LEF), the body's stable form - this is a premetabolized form that will not raise plasma levels of folic acid, recently found to be harmful (discussion at MoreLife Yahoo)
Added Noni (100%) Juice for inclusion in smoothie - antioxidant, antiinflammatory, antinociceptive (antipain), anti-cancer, anti-diabetic and antihypertensive activity - PMID 18053321, PMID 17286240.
Added PreLox Natural Sex for Men - greater source of epimedium sagittatum.
Increased Vitamin D3 and changed the form (once current liquid form supply exhausted - acquired 7/09) to version including iodine - our plasma vitamin D was still just below the optimum range and the additional sea iodine will be potentially beneficial.
Increased Pregnenalone from 1 HS - for possible increase in libido.
Increased SAMe by changing one from NF to HS - PMID 19616616 also reports that supplementation of ALA reduced SAMe levels - see note for Super r-Lipoic Acid above. Also PMID 17336420 reports isoaspartyl-damaged protein levels lower with high ratio of SAM/SAH - see note for TMG below
Increased Trimethylglycine (TMG) from 1NF/F and 1 HS - PMID 17336420 reports it prevents accumulation of isoaspartyl damaged proteins.
Increased Yohimbe Plus by moving from 1 F to HS - mfgr recommended 1 daily for maintenance. Taken since Spring 2008, experimentally for stamina, vigor and libido.
Reduced l-arginine from 4.2 g daily by removing from meal cocktail - arginine is too growth promoting and autophagy inhibiting (by stimulation of mTOR) for high use at our ages - PMID 19130170.
Reduced EPA/DHA from 4F (to 3) - PMID 19717153 suggests that high doses of DHA (above 800mg daily) will result in reduced beneficial effects.
Reduced lithium carbonate from 1 every F - to ensure sufficient quantity of Kitty's total supply for longterm usage. (Kitty's prescription for 1 daily but taken 2 days out of 3.)
Reduced Potassium citrate from effective daily of 4.6g daily - suspected intake level might be contributing to night muscle cramps; incidence much reduced since.
Reduced Super r-Lipoic Acid by delating NF dose - PMID 19616616 reports increased homocysteine level following 100mg/kg dosages of ALA in rats (~1500 mg daily in 60kg human).
Reduced Tocotrienols with sesame lignans from 2 and added Super Absorbable Tocotrienols - this was merely a change because the new ones are, presumably, more absorbable. But we also wanted to keep the old ones to have more than one source.
Replaced usage of acai capsules from LEF in Ontario and store purchased acai frozen puree in AZ with new acai powder - convenience change only.
Replaced prior Astraglus root extract with more potent version.
Restarted and replaced B1 (Thiamine) capsules with powder in "meal cocktail"; retaining usage based on PMID 16037305 which clearly showed that Benfotiamine does not replace all need for supplemental Thiamine.
Restarted DHEA 25 mg - had started as test in early 2008 to see if testosterone level increased without rise of estradiol.
Restarted Quercetin capsules (doubling previous intake) - it is a major AMPK promoter, which in turn promotes autophagy and I do not think our dosage will have any neurotoxicity as per previous concern (see changes for 4/30/08 thru 6/30/08).
Deleted pure folic acid from meal coctail mix and reduced LEF 0.13% product until supply exhausted - addition of l-methlyfolate - for reasoning see addition of l-methylfolate above.
Deleted Forskolin - it generally promotes cAMP production, which is growth promoting and autophagy inhibiting PMID 19805182 - not what we want.
Deleted daytime Melatonin - concern that it may be harmful during daytime by weakening the circadian rhythm.
Deleted Standardized Lignans - LEF discontinued; sufficient lignans in other supplements and foods taken.
Deleted l-tyrosine - it is one of the autophagy inhibiting amino acids PMID 7388042
Moved Nutrflora from Smoothie ingredients - more convenient.
Moved ProGreens from NF potion and changed from individual packets to bulk quantity - mainly because the green colored LEF Herbal Mix (necessary for complete powder mixing) is no longer available.
Moved Regimint from PF to NF - to better fit the "between meals" usage directions.
Added words "pre-sleep" to clarify usage of methylcobalamin and pantethine.
Updated link for items with new LEF number for Paradise Herb's Panax Ginseng (no ingredient change) and also for items reformulated by LEF.
Changed l-ornithine from powder to capsules - merely because easier to take presleep.
Corrected volume equivalent of Acipimox taken. Corrected listing to remove Vit B1 (Thiamine) that had been deleted in previous change - thanks to notification of error by Francois Rose.
Corrected listing to show (mega) benfotiamne at proper unit amount- thanks to notification of error by Francois Rose.
Corrected listing to show Metformin ER as it is actually being taken, including in prescription items only. Corrected listing to show Natural Relief COX-2 Inhibitor Nexrutine as it is actually being taken.
Corrected listing of size measuring spoon used for acipimox to actual practice.
Updated listing to show current name of Gentle-C for previous Ester-C.
Updated link for items with new LEF number for Paradise Herb's Panax Ginseng (no ingredient change) and also for items reformulated by LEF.
1/10 thru 2/28/10 Added Caloric Restricton Mimetic Formula, replacing Resveratrol products as supply is exhausted - product contains resveratrol plus additional ingredients.
Added Euopean Leg Solution (Diosmin 95) for 3 month usage and repeats as needed - to reduce/eliminate areas of small spider veins on lower calves/ankles.
Added Goji100 (100% goji juice) to smoothie contents - supplement amount of dried berries.
Added Krill Oil - contains unique phospholipids of both EPA and DHA plus more astaxanthin.
Added pioglitazone - it is a CR mimetic drug which should lower serum glucose.
Added Theralac, starting with 1 every meal for 2 weeks - a unique probiotic supplement.
Added Zyflamend - Antiinflammatory complex containing 5 ingredients not in anything else.
Restarted -BPAP - topical Deprenyl supply exhausted and no longer available from compounding pharmacy at reasonable price.
Replaced DHEA capsule with sublingual tablet - 1 less item to swallow.
Increased Arthro-Immune Joint Support from 1 - deletion of single ingredient BioCurcumin product.
Increased Omega 3 EPA/DHA from 3F - because of fewer fish at meals with further reduction of protein intake.
Increased Mega Lycopene from 1F - beneficial to prostate health.
Increased Super Upiquinol (CoQ10) from 2F - the benefits of CoQ10 keep piling up and the natural statin in Red Rice Yeast reduces body's creation of it.
Replaced B5 (pantothenic acid), Taurine, TMG capsules with powder to be used in "meal cocktail" - reduction of capsules/tablets consumed to control Kitty's IBS symptoms.
Replaced BHT powder in olive oil used in "meal cocktail" with capsules - capsules now available and less work.
Replaced Enhanced Irvingia (Integra Lean Irvingia) with Optimized Irvingia - Improved LEF product.
Replaced ProGreens with Vital Greens - LEF introduced its own multi-greens product. [meal cocktail]
Deleted Nutraflora (in "meal cocktail") - replaced previously by Agave Digestive-Immune Support.
Deleted sesame seeds as regular nutritional intake item - too much omega-6 and too high in methionine - still get the important lignans in other supplements.
Dual Action Cruciferous changed by LEF to Triple Action - now contains apigenin.
Corrected notation for LEF Mix from Low Niacin - has been regular niacin content since 7/07.
Corrected meal cocktail powder listing removing Herbal Mix - replaced in Oct 2008.
Updated LEF numbers for: DNA Protection, EPA/DHA, LEF Mix, Super Ubiquinol - constituent changes.
Increased Paul's age - 72nd birthday 2/26!
3/10 thru 8/20/10 Added Aloe Gold to smoothie - also substitutes when in Ontario for Trader Joe aloe that is added to wine in AZ; wine (and all liquor) much more expensive in Canada.
Added Anti-Oxidant Rejuvenating Foot Cream - improve and maintain good feet skin quality.
Added Optimized Saffron - to maintain positive mood and energy on fasting day afternoons and evenings.
Added Ultimate Advanced Flora - for more sources of bio-flora; reduced JarrowDophilus so no more total amount of pills
Added Sodium Selenite - valuable form of inorganic selenium for cancer prevention PMID 20492335 (and others).
Increased Irvingia by adding 2nd set of 2 before 2nd half of long single daily meal on 2 days out of 3 - mfg recommends 2 taken prior to meals.
Increased SAMe by replacing 200mg tabs with 400mg version - because of reduced meat and methionine consumption.
Increased Mega Silymarin from one [F] - liver and kidney protective.
Modified Acipimox usage by not taking after any more than mildest injury until healing well observed - increased autophagy conflicts with healing process.
Reduced by half total generic ALT-711 (Alagebrium chloride) intake (from 144mg) by preparing meal cocktail powder with previous dosage of chemical in only half the total quantity and then cycling usage of the two halves for equal elapsed times of approximately 11-12 days - based on a negative preliminary result from a mouse longevity test; still think it is beneficial as part of the whole set of supplements and that cycling may ameliorate any negative effects.
Reduced N-acetyl-cysteine from 1 HS and 1NF/F eliminating doses when fasting - to reduce negative effect on autophagy PMID 20571221.
Replacement of several powder items (in Meal Cocktail) with capsules as supply is exhausted: Thiamine (B1), B5 (Pantothenic acid), L-Carnitine, RNA - LEF has discontinued these powders or is in the process of doing so.
Replaced Choline Bitartrate with Choline Chloride - LEF discontinued former.
Replaced Biosil capsules with liquid version - order error but will retain as is 1 less capsule.
Replaced Blueberry Extract with Pomegranate & Cocoa Gold with BlueBerry Extract and increased Pomegranate Full Spectrum started in Spring - LEF appears to be discontinuing use of Cocoa Gold in products; we know not why.
Replaced NALC with Beta Alanine - to eliminate the high cost per usage of the former and for muscles the latter may work as well or better.
Replaced Soy Power with Soy Protein Concentrate (in smoothie) and added Ultra Soy Extract - LEF discontinued the former and latter provides standardized sources for replacement of genistein and daidzen.
Replacement of Lutein Plus (meal cocktail) with increased Super Zeaxanthin when supply of former exhausted (1NF/F) - LEF discontinued product.
Replaced products with newer versions brought out by LEF: Berry Complete, Calorie Restriction Mimetic Formula, CranMax, Endothelial Defense, Natural Prostate - older versions discontinued.
Restarted Optimized Resveratrol (new version w/Synergistic Grape-Berry Actives) - to increase resveratrol a little and get more fisetin.
Stopped pioglitazone - PPRAgamma promoter for increasing insulin sensitivity but recently found to possibly promote thymic involution PMID 20374200.
Deleted Black Currant from cereal - modified cereal recipe; full amount in smoothie.
Deleted Korean Angelica and Silibinin+ - discontinued by LEF.
Deleted Rutin and Hesperidin powders (from meal cocktail) and also Cocoa Gold with Beta Glucan powder and Polyphenols with Cocoa Gold when supply exhausted - LEF is discontinuing these items; sufficient intake in other items until appropriate replacements available.
Deleted generic EUK-189 - evidence not gastric bioavailable and cost per usage.
Updated Calcium Pyruvate dosage amount - manufacturer change.
Updated note for preparing "meal cocktail" - to correspond to current practice.
Added withhold for Metformin following moderate injury or with illness - autophagy not desired at these times.
Added Note 7 - reduce confusion for opening javascript links.
Added listing for infrequent use of Fast Acting Joint Relief (as is present on Kitty's page) - to correspond with usage.
Consolidated listing of Metformin under Prescription Medication for all dosage times.
Corrected listed dosage amount and time of Vit D3.
Corrected listed amounts of liquid items in smoothie to what is actually used.
9/10 thru 2/28/11 Added Boswella cream as PRN for joint application after injury if discomfort continues more than day or interferes with sleep.
Added Copper capsules - maintain good balance w/ zinc after removal from several LEF products.
Added GingerForce.
Added PPQ (Pyrroloquinoline quinone) - insufficient qty from Mitochondrial Energizer as taken.
Added Pure Plant Protein w/ Branched Chain AA, as PRN for significant injury (in reserve; have not had reason for usage yet).
Added Lifeshield Immunity mushroom blend - replaces maitake and adds others.
Added Stabilium as PRN for anticipated highly stressful situations.
Added Strontium.
Increased 5-Loxin from 1F.
Increased ArthroMax after 2 mo decrease from 4F to 1F - Start of R knee pain w/dancing since mid-January.
Increased Ashwaghanda from 1NF - PMID21170205
Increased MSM from 1NF/F - Start of R knee pain w/dancing last 3 wks.
Increased Blueberry w/ Pomegranate from 1F.
Increased N-Acetyl Cysteine from 1F - PMID1974755
Increased r-alpha Lipoic acid from only 1HS - PMID20934512
Increased Rhodiola from 1F.
Modified Alagebrium Chloride dosage further by reducing the nominal meal dosage to 90 grams of which Paul's is 120% (108 grams) and including this amount in in alternate meal cocktail powder mixing (45 days with, 45 days without).
Modified Panax Ginseng from 2PF.
Modified Silimarin Mega from 2F - distributed dosage
Reduced Low Dose Asprin from 1NF/F - PMID21245996
Reduced CR Mimetic Formula from 3F [1F 1st eating day only] - excessive Resveratrol MoreLife Yahoo Msg #2292.
Deleted B12 Elegen - discontinued by LEF, no reason given.
Deleted Grape extract w/ Resveratrol - excessive Resveratrol MoreLife Yahoo Msg #2292.
Corrected Berry Complete to show HS dose - have been taking along with F dose.
Corrected IP6/Inositol designation - CellForte is the company name.
Corrected Endothelial Defense from 2NF [2F] - typo error.
Corrected Pyridoxamine stated dosage of 480 mg in each meal to what has been used since March 2009.
Updated product numbers for Berry Complete [1406], Chlorophyllin with Zinc [1548], LEF mix [1557], Mitochondrial energizer [1568] - LEF product modifications.
Replaced Blueberry Extract (#1214) with Blueberry Extract with Pomegranate [#1438] and correspondingly reduced Pomegranate Full Spectrum to previous dosage (1F) - LEF made available previous product without Cocoa Gold, which it had discontinued earlier (got that?!...)
Replaced VitD w/ SeaIodine with Vits D&K w/ SeaIodine [1472] - eliminates separate VitK cap.
Replaced DMAE (37%) powder with capsule version - LEF has discontinued powder.
Replaced 1/2 of Vital Greens with equivalent amount of ProGreens - LEF product contains stevia resulting in overly distasteful meal cocktail (to me).
Corrected listing by showing BHT capsules which have been taken since bulk supply was exhausted in early 2010 and stated in Changes 1/10 thru 2/28/10.
Increased age to 73 - Happy Birthday, Paul!
3/11 thru 8/31/11 Added Cerimides, Skin Restoring [1502 1F; P2F] - counter tendency towards dry itchy skin & maintain skin health with aging.
Added Derma Whey [2f] - maintain skin health with aging.
Added Essential Plant Lipids Reparative Serum - for skin application to lessen tendency to itch in various locations and reduce scarring on shins from previous injury.
Added Fucoidan, Optimized [F, NFfstg] - source of Undaria pinnatifida, the species of seaweed used in a majority of scientific studies on fucoidan.
Added Ideal Bowel Support containing Lactobacillus plantarum.
Added Interplexus Seriphos [2PF split before ea sitting] - additional source of serine.
Added Natural Sleep (w/o Melatonin), Enhanced [1HS] - to get Bioactive Milk Peptides and amla (Indian gooseberry).
Added Niacinamide [2F] - may be an important form of B3.
Added pTeropure (pterostilbene) [1F] - a CR mimetic similar to resveratrol.
Added Relora [1PF] as replacement for Natural Relief COX-2 Inhib Nexrutine, discontinued by LEF - contains Phellodendron amurense and Magnolia officinalis both showing potential for cortisol regulation.
Added (in April) and deleted in August Astral Fruit (RevGenetics) - not currently available.
Increased CR Mimetic Formula from 1F 1st eating day only - increase desirable fisetin, available only in this LEF product.
Deleted Pantethine 25 mg tabs (Source Naturals) - LEF discontinued carrying and its replacement is 450mg capsule by Jarrow! Therefore replacing NF dose of Pantothenic Acid (500mg) with Jarrow product.
Deleted Black Currant Extract Juice by Jarrow - discontinued by LEF without comparable replacement.
Deleted Optimized Resveratrol - to reduce quantity which is hormetic and may be in unhealthy range at the high doses of many LEF products PMID 21115559 and PMID 21115567
Increased Yohimbe Plus [2HS] - additional Ashwaghanda PMID21170205
Modified taking of micronized creatine from inclusion in meal cocktail - studies show that it is more effective when taken before and after exercise.
Modified taking of HCA from 3NF/2PF - more in line w/ mfgr recommendation.
Replacing Chondroitin with Glucosamine/Chondroitin - L knee & thumb discomfort; began in April w/ improvement since.
Replaced Lecithin w/ B5 & BHA (#19) with plain version (#20) when LEF discontinued the former.
Restarted Branched Chain Amino Acid (#1253) [4F] after ceasing usage for couple years due to TOR implication research - too many studies show benefits for liver, muscles etc that decided to suffer the TOR promotion effects of the leucine component, particularly - wish that we could get BCAA without leucine.
Links updated for several items [aspirin [#1066] - no identifiable change; Booster [#1590] - removed ingredients; Optimized Folate [#1439 was 1312] - no identifiable change; PEAK ATP w/ Glycocarn [1323 was 923] - no identifiable change - those w/ changes noted on ingredient spreadsheet.
Revised timing for PF (pre-food) items from 45-60 mins before (sittings) of extended meal.
Explanation added for splitting of multiples of same supplement between 2 sittings of extended meal.

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Page last updated 10/5/2011
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